Lions Vs 49ers Prediction 2025 Football. Take the lions to grab the win on the road against a struggling 49ers team. The winning team model predicts the lions will win this game with 64.0% confidence, based on game simulations,.

Detroit lions vs san francisco 49ers predictions, picks, odds and best bets for their nfl week 17 monday night football game. Lions vs 49ers over/under this total has come down from the opener of 52.5 points and sits at 50.5 o/u, just a half point short of the key total number of 51 points (third.